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Simplicef (Cefpodoxime Proxetil) for Dogs

By | Last Updated : 3rd March 2018

What is Simplicef (cefpodoxime proxetil)

Simplicef (generic name cefpodoxime proxetil) is an antibiotic veterinarian medication of the cephalosporin class, used to treat various infections caused by gram-positive and gram-negative bacteria. Particularly effective against bacteria like Escherichia coli, Staphylococcus intermedius, and Streptococcus canis [5], cefpodoxime proxetil is prescribed to treat infections of the ear, skin (like staph and yeast infections), respiratory tract, and bone. It is also effective against pneumonia, infected wounds, and UTIs like a bladder infection [5, 6].

Quick Information

Simplicef for Dogs

Generic Name

Cefpodoxime proxetil

Brand Name




Who can take it

Dogs, cats

FDA Approved

Yes [2]


Prescription only

Available forms

Tablets, oral suspension, syrup

How does it work in dogs

Cefpodoxime proxetil primarily works by preventing the infection-causing bacteria from developing a protective cell wall, thus leaving it vulnerable, leading to its instability and eventual death [5, 6].

Simplicef dosage for dogs

Be sure to follow the vet’s prescription; the dosage usually prescribed is 2.5-5 mg/lb (5-10 mg/kg) of the dog’s body weight, given once daily for a week, or till 3 days after the clinical signs of infection disappear [6].

It is always advisable to complete the course of treatment; otherwise, the infection may recur and grow resistant to this antibiotic [2].

In case of a missed dose, give it as soon as you remember. But, if it is almost time for the next dose, skip the one you have missed and continue with the regular dosing schedule [3].


  • Vomiting
  • Diarrhea
  • Loss of appetite (your dog not eating as much as it used to for subsequent meals)
  • Rashes
  • Excessive drooling
  • Excitability (your dog being startled easily, or remaining overexcited all the time) [2, 3]

Dogs that are allergic to the medication may exhibit symptoms like labored breathing, tiredness, vomiting, seizures, and hives.

Signs of overdose

  • Abdominal cramps (your dog lying curled up guarding its stomach, which might be swollen as well)
  • Watery or bloody stools
  • Nausea
  • Skin reactions (e.g. rashes, excessive scratching) [1]

Call the vet immediately, or get in touch with the ASPCA Animal Poison Control Center Helpline (1-888-426-4435) if you notice any of the above side effects or symptoms.

Contraindications: When not to give

Cefpodoxime proxetil should not be given to dogs that are:

  • Allergic to antibiotics like cephalosporin drugs and penicillins [6].
  • Pregnant or lactating [6].
  • Suffering from epilepsy, seizures, or kidney disease [2].

Make sure to let the vet know if your dog is taking any medications or supplements to avoid any chances of drug interactions. It is usually not given along with blood-thinners like neomycin and gentamicin. The antibiotic might increase the blood volume, causing certain adverse health effects if used along with uricosuric drugs (that get rid of the excess uric acid in the body) like probenecid.



    1. Cefpodoxime Side Effects in Dogs – VetInfo.com
    2. Cefpodoxime Proxetil – PetMD.com
    3. Cefpodoxime Proxetil – 1800PetMeds.com
    4. Cefpodoxime for Dogs – VetInfo.com
    5. Cefpodoxime Proxetil – DiamondbackDrugs.com
    6. Cefpodoxime Proxetil (Simplicef®) for Dogs and Cats – PetPlace.com
    7. Simplicef – UunitedPharmacies.md

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