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Denosyl for Dogs

By | Last Updated: 22nd February 2023

What is Denosyl

Denosyl is a supplement given to dogs and cats to curtail a number of liver problems and increase hepatic function. Its active ingredient is S-Adenosylmethionine [1, 3].

How does it work in dogs

Denosyl works by increasing glutathione antioxidant levels in the body, which helps in fighting various toxins that may be harmful for the liver. It also helps in repairing damaged liver cells [2, 4].

Quick Information

Denosyl for Dogs

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Generic name: S-Adenosylmethionine (SAMe) [1]

Brand names: Denosyl

Type: Supplement [3]

Who can take it: Dogs and cats [1]

Availability: Only from veterinarians [6]

Available forms: Chewable tablets [1]

When may Denosyl be prescribed

It is not always possible to detect the signs of liver damage in your dog. But, in some cases, there are certain symptoms that might indicate problems in the functioning of the liver. Make sure to contact your vet if you see any of the following symptoms in your pet:

  • Sudden weight loss
  • Loss of appetite
  • Persistent diarrhea and/or vomiting
  • Excessive thirst
  • Urinating more than usual

Denosyl dosage: How much to give to your pet

Never give it to your pet without consulting a veterinarian. Doses are prescribed based on the weight of the pet [1]; following are the usual dosage recommended for small, medium, and large dogs:


Dosage per day

For small dogs
Up to 12 lbs (5.5 kg) 90 mg tablet x 1
For medium-sized dogs
13-34 lbs (6-15.5 kg) 225 mg tablet x 1
For Large dogs
35-65 lbs (16-29.5 kg) 425 mg tablet x 1
66-120 lbs (30-54.5 kg) 425 mg tablet x 2
Over 120 lbs (54.5 kg) 425 mg tablet x 3

Tablets are best absorbed when they are administered on an empty stomach, about an hour before feeding. Administer the tablet whole, do not crush or split it, and follow the directions on the packaging [5].

In the absence of Denosyl, you can give your pet Denamarin as an alternative, but do not do so without talking to the vet first. These two products are almost same, with Denamarin having the additional active ingredient silybin (milk thistle extract) that protects the liver further [1].

Possible Drug Interactions

Denosyl does not usually have any interactions with other drugs [1].

Denosyl side effects

Denosyl does not have any side-effects as long as it is given in the prescribed dose and directions on the packaging are followed [1].


    1. Denosyl – Denosyl.com
    2. Managing Canine Liver Disease with Denosyl –  VetInfo.com
    3. Denosyl – EntirelyPets.com
    4. Denosyl & Denamarin Tablets for Dogs and Cats – AussiePet.com.au
    5. Denosyl – Drugs.com
    6. Denosyl – VetDepot.com
    7. What is Denosyl Used for – EntirelyPets.com

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