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Denamarin for Cats

By | Last Updated: 23rd February 2023

What is Denamarin

Denamarin is a nutritional supplement consisting of S-Adenosylmethionine (SAMe) and the antioxidant Silybin. It is given to cats with a compromised liver for improving its function by increasing the liver-protecting antioxidant levels [2]. It is likely to work better when started in the early to middle stages of liver damage. However, it remains a supplement and not a replacement for prescribed hepatic medication [3].

Quick Information

Denamarin for Cats

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Generic Name: S-Adenosylmethionine/Silybin A+B

Brand Name: Denamarin

Type: Supplement

Who can take it: Cats, dogs

FDA Approved: Yes, as a supplement

Availability: Over-the-counter [3]

Available forms: Tablets

How does Denamarin work in cats

The active ingredient of S-Adenosylmethionine (SAMe) along with Silybin A and B, provide a two-level treatment for damaged liver, with the former raising the glutathione levels, an antioxidant that protects the liver from toxins and free radicals. SAMe may also promote cell regeneration in the liver as well as improve bile flow [6].

The antioxidants Silybin A and B help in protecting against liver damage, preventing oxidization of certain cell types, and improving protein synthesis. Studies have shown silybin to be effective in the protection of liver tissues due to acetaminophen poisoning.

Dosage: How much to give

Although available over the counter, never give this supplement without first consulting with a veterinarian [3]. There are three sizes of the tablet, based on their strength – large, medium, small. The small tablets are usually prescribed for cats, given once or twice daily depending on your cat’s body weight [1]:

Denamarin is best absorbed if given on an empty stomach, about one hour before the first meal in the morning [4]. Administer the tablet in whole without crushing or splitting it.

If you miss giving a dose, give it as soon as you remember. But if it is already time for the next dose, skip the missed one and continue with the regular schedule [5].

Possible Side effects

Denamarin has no known side-effects in cats [3]. But if you notice any adverse effects or discomfort, or even suspect an overdose, it is advised to get in touch with the vet immediately.

Contraindications: When not to give

Denamarin is ill-advised for kittens less than six weeks of age [3]. Additionally, it is never recommended as a precautionary measure against liver damage.

This supplement is not yet known to interact with any medication [3]. Do inform your vet about any drugs you may be giving your cat.


    1. Denamarin Liver Health Support for Cats – Denamarin.com
    2. Denamarin Tablets – 1800PetMeds.com
    3. Denamarin for Dogs And Cats: Managing Liver Disease – PetCareRX.com
    4. Denamarin – Protexin.com
    5. Denamarin – AnimalClinicatThorndale.com
    6.  Denamarin Chewable Tablets – Drugs.com

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